Cyclobenzaprine 10Mg Flexeril 1000 Tabs

For most patients, the recommended dose of FLEXERIL is 5 mg three times a day. Based on individual patient response, the dose may be increased to 10 mg three times a day. Use of FLEXERIL for periods longer than two or three weeks is not recommended. Elderly patients seem to tolerate cyclobenzaprine less and may develop hallucinations as well as significant anticholinergic side effects, such as sedation. The use of significant lower dosing schedules in elderly patients may be prudent.

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Less frequent dosing should be considered for hepatically impaired or elderly patients (see PRECAUTIONS, Impaired Hepatic Function, and Use in the Elderly). Older adults may be more sensitive to the effects of this medicine. Do not use cyclobenzaprine if you have taken an MAO inhibitor in the past 14 days, such as isocarboxazid, linezolid, phenelzine, rasagiline, selegiline, or tranylcypromine. Animal studies don’t always predict the way humans would respond.

It is unknown if this medication passes into breast milk. Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

What should I know about storage and disposal of this medication?

Ell your doctor if your condition lasts after 2 to 3 weeks or if it gets worse. Since overdosage is often deliberate, patients may attempt suicide by other means during the recovery phase. Safety and effectiveness of FLEXERIL in pediatric patients below 15 years of age have not been established. It is not known whether this drug is excreted in human milk. Because cyclobenzaprine is closely related to the tricyclic antidepressants, some of which are known to be excreted in human milk, caution should be exercised when FLEXERIL is administered to a nursing woman.

Although rare, deaths may occur from overdosage with FLEXERIL. Multiple drug ingestion (including alcohol) is common in deliberate cyclobenzaprine overdose. As management of overdose is complex and changing, it is recommended that the physician contact a poison control center for current information on treatment. Signs and symptoms of toxicity may develop rapidly after cyclobenzaprine overdose; therefore, hospital monitoring is required as soon as possible. The acute oral LD50 of FLEXERIL is approximately 338 and 425 mg/kg in mice and rats, respectively.

When certain drugs are used with cyclobenzaprine, they may cause more severe side effects such as increased drowsiness or sedation. A person should ask their doctor whether it is safe to combine another medication with cyclobenzaprine and take care not to operate any machinery while taking it. Taking this drug with an MAOI or within 14 days of stopping an MAOI could increase your risk of serious side effects.

Drug Interactions

Cyclobenzaprine may be used as part of combination therapy. This means you may need to take it with other medications. Ask your pharmacist any questions you have about refilling your prescription. It works by blocking nerve impulses (or pain sensations) that are sent to your brain. The best way to know how often you should be taking cyclobenzaprine is to consult your doctor and follow the directions as prescribed. Because of its effect on the brain, cyclobenzaprine can cause sleepiness and impair judgment.

• It accumulates and, if dosed three times a day, can reach steady-state within 3-4 days.
• Multiple drug ingestion (including alcohol) is common in deliberate cyclobenzaprine overdose.
• A theoretical half-fragment weight (THW) was used to calculate percent weight and drug content ranges from the average weight of the tablets for each trial.
• Observation with cardiac monitoring and observation for signs of CNS or respiratory depression, hypotension, cardiac dysrhythmias and/or conduction blocks, and seizures is necessary.

That’s why it’s important to know your dosage, understand how long the effects last, and how long it stays in your system. After each tablet was split, the individual fragment weights were measured and recorded. A theoretical half-fragment weight (THW) was used to calculate percent weight and drug content ranges from the average weight of the tablets for each trial. Prior to splitting, each whole tablet was weighed on a special scale and the weight was recorded. The participants practiced the splitting technique with each device with up to four tablets; the weights of which were not included in the analysis.

CLINICAL PHARMACOLOGY

Call your doctor or local poison control center if you think you’ve taken too much of this drug. Call 911 or go to the nearest emergency room immediately if your symptoms are severe. This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information. flexeril special instructions Using cyclobenzaprine with other drugs that make you drowsy can worsen this effect. Ask your doctor before using opioid medication, a sleeping pill, a muscle relaxer, or medicine for anxiety or seizures. Do not use cyclobenzaprine if you have taken an MAO inhibitor in the past 14 days.

Tell your doctor all medications and supplements you use. Tell your doctor if you are pregnant or plan to become pregnant during treatment with Flexeril. It is unknown if Flexeril passes into breast milk or if it could harm a nursing baby.